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Biomedical Engineering Design Projects

Application of Mechanical Stress to Hydrogel Scaffolds for the Study of Cardiac Hypertrophy

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Project Overview

A constant mechanical stress will be placed on a hydrogel mold that contains heart cells. The device will allow researchers to see in vitro if the added stress causes the heart cells to enlarge.

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Project Status

Team

Team Members from Left: Betsy Appel, Joe Grudzinski, Alyssa Walsworth and Megan Buroker

Preliminary testing with jello

Preliminary testing of the compression device with jello to see if any sliding would occur

final tension desigm

The tension design with a cube of hydrogel placed on the grips

compression design

The final compression design consisting of two plates made of high density polycarbonate, attached at the corners with nylon skrews and nylon washers

normal cells

Image of fluorescent marked cells before compression, note the circular shape of the cells

compressed cells

Image of the fluorescent-marked cells after compression, note the oval shape of the cells

Progress Report Archive.

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Project Timeline

Week Reporting Period Beginning Activities
1 January 21 First Team Meeting. Met with Client. Began PDS and literature search
2 January 28 Conduct literature and patent search
3 February 4 Begin brainstorming and choose three designs
4 February 11 Work on Midsemester presentation
5 February 18 Obtain client feedback. Complete midsemester paper
6 February 25 Brainstorm how to integrate two designs
7 March 4 Start prototyping
8 March 11 Continue prototyping
9 March 18 Prototyping
10 March 25 Complete prototyping, Begin preliminary testing
11 April 1 Test prototypes, and modify as needed
12 April 8 Continue protype testing
13 April 22 Complete prototypes and testing. Begin work on Final presentation
14 April 29 Continue work on Final presentation
15 May 6 Finish the Final Presenation and Final Paper

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Presentations and Reports

pdf icon Product Design Specifications (Feb 16 2005, 20 kb)
ppt icon Midsemester Presentation (Feb 16 2005, 873 kb)
pdf icon Midsemester Paper (Feb 25 2005, 218 kb)
pdf icon Final Paper (May 4 2005, 439 kb)
jpg icon Poster (May 4 2005, 1501 kb)

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Contact Information

Project Team

Project Advisor and Client

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Owner: Willis Tompkins, Ph.D.
Author: Alyssa Walsworth
Webmaster: Andrew L. Wentland
Created: Jan 26 2005
Content updated: May 4 2005

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